Elizabeth Garrett-Mayer, PhD joined the American Society of Clinical Oncology (ASCO) in 2017 as Center for Research and Analytics (CENTRA) Division Director for Biostatistics and Research Data Governance. She was appointed CENTRA’s first Vice-President in 2022.Uncertainty about optimality of doses of anti-cancer agents approved in recent years, including PD-L1 blockade agents and targeted agents, has led to a movement in the oncology drug development field to reconsider the traditional approach for drug development. Following in the path of approvals for nivolumab and pembrolizumab, trial designs for dose finding trials have ballooned from sample sizes in the range of 12-50 to the hundreds or more. In addition, post-marketing trials have demonstrated that lower doses of certain drugs may be as efficacious as approved doses. The has contributed to a renewed focus on ‘dose optimization,’ causing statisticians, researchers, patient advocates and regulators to realize the profound inadequacies of traditional phase I dose finding designs. Trial approaches need to incorporate the adaptive nature of a seamless toxicity-efficacy paradigm, while maintaining practical aspects of trial implementation, statistical properties, endpoint measurement and safety and well-being of patients. This talk will discuss these aspects and provide recent context of drug approvals in oncology.Frontiers in Biostatistics is a monthly seminar series featuring guest #biostatistics experts, hosted by the Department of #DataScience at Dana-Farber Cancer Institute in Boston, MA.
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Is your company utilizing Local SEO for generating leads? Our SEO Wizard friend shares some powerful tips:In this clip from the UpTech Report, the CEO of Improovy, Andre Kazimierski shares how he took his painting contracting company and optimized it for the digital age. He is an expert in local SEO strategy and search engine marketing, and today, he is going to share a few of his secrets. Improovy’s platform uses AI and algorithms to match up homeowners with local painting contractors who are qualified for the job, but SEO is pretty much the key to keeping his entire operation running.Homeowners put a work order in on the website, receive a quote, and after accepting, the painters show up at the house with brushes in hand.But how does Kazimierski take on the giant task of generating leads and unifying the fragmented painting industry? For starters, it’s all about knowing what potential customers are typing into Google and their search intent. #LocalSEO #DigitalMarketingMore information: https://www.improovy.com/—Subscribe to UpTech Report—Website – https://www.uptechreport.com/YouTube – http://bit.ly/3bQFNsXLinkedIn – https://bit.ly/2Y7d8rPTwitter – https://twitter.com/UpTechReport
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